Killer artificial antigen-presenting cells: a novel strategy to delete specific T cells.

Preferential T cell Expansion by Artificial Antigen Presenting Cells Expressing 4-1BBL Alone or in Combination with CD80 or CD86

Killer-Artificial-Antigen-Presenting-Cells (КaAPC): A Novel Strategy to Delete Specific T Cells

1 University of Regensburg, Department of Internal Medicine I, 93053 Regensburg, Germany 2 University of Regensburg, Division of Hematology and Oncology, 93053 Regensburg, Germany 3 University of Erlangen-Nuernberg, Department of Internal Medicine V, 91054 Erlangen, Germany 4 UM/sylvester comprehensive Cancer Center Leonard M. Miller School of Medicine, Miami, Florida 33136, USA 5 Division of I...

The role of T helper 9(Th9) against Infectious Diseases

Background and aims: Infectious diseases are disorders caused by organisms such as bacteria, viruses, fungi or parasites .The Th9 subset develops in response to combined signals from TGF-b and IL-4 among a cacophony of other cytokines in an extracellular milieu. T helper 9 (Th9) cells,  as a novel CD4 T cell subset, seem to play a complex role in the outcome of specific immune responses. In thi...

Killer artificial antigen presenting cells (KaAPC) for efficient in vitro depletion of human antigen-specific T cells.

Current treatment of T cell mediated autoimmune diseases relies mostly on strategies of global immunosuppression, which, in the long term, is accompanied by adverse side effects such as a reduced ability to control infections or malignancies. Therefore, new approaches need to be developed that target only the disease mediating cells and leave the remaining immune system intact. Over the past de...

Artificial antigen-presenting cells: artificial solutions for real diseases.

Adoptive immunotherapy, which involves the transfer of autologous antigen-specific T cells generated ex vivo, is a promising strategy to treat a variety of life-threatening diseases. Unfortunately, current approaches for generating sufficient numbers of antigen-specific T cells lack the ability to serve as reproducible and economically viable methods. This has spurred the development of both ce...